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Ingredients6 min readJanuary 10, 2025

Panthenol (Vitamin B5): The Ultimate Skin Soother

Panthenol hydrates, repairs the barrier, and reduces irritation—making it the perfect companion for active ingredients like retinoids and acids.

Dr. Sarah Chen

Dr. Sarah Chen

Board-Certified Dermatologist

Panthenol (Vitamin B5): The Ultimate Skin Soother

Panthenol (Vitamin B5): The Ultimate Skin Soother

Panthenol, also known as Provitamin B5, has 88-92% dermatologist support for its exceptional ability to hydrate, soothe, and repair the skin barrier.

What is Panthenol?

Panthenol is the alcohol form of pantothenic acid (Vitamin B5). When applied to skin, it converts to pantothenic acid, which is essential for healthy skin function.

Key Benefits

1. Deep Hydration

Panthenol is a humectant that attracts and holds water in the skin, providing lasting hydration without heaviness.

2. Barrier Repair

It supports the synthesis of lipids and proteins needed for a healthy skin barrier, reducing transepidermal water loss (TEWL).

3. Anti-Inflammatory

Panthenol calms irritated skin, making it valuable for conditions like eczema, rosacea, and post-procedure care.

4. Wound Healing

Studies show panthenol accelerates epithelialization (skin healing) and improves wound closure.

Why Dermatologists Love Panthenol

Benefit Clinical Evidence
Reduces TEWL Up to 22% improvement in barrier function
Decreases irritation Significantly reduces redness from irritants
Enhances hydration Increases stratum corneum hydration
Supports healing Accelerates wound healing by 20-30%

The Perfect Pairing Ingredient

Panthenol excels when paired with potentially irritating actives:

  • With Retinoids: Reduces dryness and peeling
  • With AHAs/BHAs: Minimizes irritation while allowing exfoliation
  • With Vitamin C: Provides soothing balance
  • With Niacinamide: Complementary barrier support
  • How to Use Panthenol

  • Concentrations: Look for 1-5% in formulations
  • Apply after actives to soothe and protect
  • Use AM and PM - it's gentle enough for twice daily
  • Look for it in moisturizers, serums, and masks
  • Who Benefits Most?

  • Sensitive skin types - calms reactivity
  • Dry skin - provides lasting hydration
  • Retinoid users - minimizes retinization irritation
  • Post-procedure - supports healing after peels or lasers
  • Eczema-prone - reduces flares
  • The Bottom Line

    Panthenol is one of the most versatile and well-tolerated ingredients in skincare. It's the ideal "supporting actor" that makes your other actives work better while keeping skin calm and hydrated.

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    Tags

    panthenolvitamin b5soothingbarrier repairhydrationsensitive skin

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